At the end of the course, the student should be able to:
a1. Explain the basic concepts of disease formation.
b1. Illustrates the physiologic changes brought about by various disease processes.
a2. Describe the process of cell growth, regeneration and wound healing.
b2. Discuss the principles and procedures in cell and tissue preparation and processing.
b3. Discuss the principles and procedures in autopsy and biopsy
b4. Outline the development of diseases as a result of genetic, nutritional, environmental, infectious, immunological or hemostatic disturbances.
a3. Recognize the ultrastructure of cells undergoing changes due to pathology.
c1. Demontrates the nurses’ personal, social and professional responsibilities in helping restore or maintain good health, with high moral and ethical standards.
I. Introduction 1. Review of Normal Histology 2. Definitions 3. Branches of pathology 4. Diseases 5. Etiology 6. Pathogenesis 7. Morphologic changes and functional derangements 8. Clinical Significance II. Cellular Injury and Cell Death 1. Normal homeostasis 2. Reversible cell injury 3. Irreversible cell injury 4. Cell death 5. Apoptosis 6. Necrosis III. Cellular Adaptation 1. Terms 1.1. Atrophy 1.2. hypertrophy 1.3. Hyperplasia 1.4. Metaplasia 2. Definition, types, etiologies of different cell adaptation. 3. Degeneration, pigmentation, pathologic accumulation of chemicals. 3.1. Etiology 3.2. Types. 3.3. Pathophysiology. 4. Pathologic calcification. IV. Inflammation and Repair 1. Definition 2. Etiology 3. Cardinal signs 4. Classification 5. Mechanisms of acute and chronic inflammation 6. Cells of inflammatory response 7. Tissue healing and repair V. Etiology of Diseases 1. Genetic Diseases 1.1. Definition 1.2. Classification 2. Hemodynamic Disorders 2.1. Definition 2.2. Pathogenesis 2.3. Classification 3. Nutritional Diseases 3.1. Definition 3.2. Pathogenesis 3.3. Classification 4. Metabolic Diseases 4.1. Definition 4.2. Pathogenesis. 4.3. Causes. 5. Neoplasia. 5.1. Definition. 5.2. Pathogenesis. 5.3. Classification. 5.4. Causes. 6. Infectious Diseases. 6.1. Definition. 6.2. Pathogenesis. 6.3. Classification. 6.4. Causes. 7. Diseases caused environmental, Chemical and physical injuries. 7.1. Definition. 7.2. Pathogenesis. 7.3. Classification. VI. Biopsy 1. Excision 2. Incision 3. Core-needle biopsy 4. Fine needle aspiration biopsy 5. Processing VII. Post mortem Examination/PME (Autopsy) 1. Signs of somatic death (Post mortem changes) 1.1. Rigor mortis 1.2. Algor mortis 1.3. Post mortem clotting of blood 1.4. Discoloration of tissues 1.5. Putrefaction 1.6. Desiccation 2. Purpose of PME 3. Techniques of PME 4. Requirements of PME 5. Personnel involved in PME 6. Medical autopsy vs. medico-legal autopsy 7. Classification of autopsy specimens. 8. Proper handling of autopsy specimen
Prezbindowski, Kathleen Schmidt. Study Guide to Accompany Porth’s Essentials of Pathophysiology, 2nd Edition. Philapdelphia, USA: Lippincott Williams and Wilkins. 2007.
LiVolsi, Virginia, et. al . Pathology, 3rd Edition. Harwal Publishing. 1994
